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Article

Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease.

World journal of gastroenterology - 21 Jan 2016

Spalinger Marianne R, McCole Declan F, Rogler Gerhard, Scharl Michael

Abstract excerpt

Genome wide association studies have associated single nucleotide polymorphisms within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) with the onset of inflammatory bowel disease (IBD) and other inflammatory disorders. Expression of PTPN2 is enhanced in actively inflamed intestinal tissue featuring a marked up-regulation in intestinal epithelial cells. PTPN2 deficient mice suffer...

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Source

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Identifiers

PMID: 26811645
DOI: 10.3748/wjg.v22.i3.1034
PMCID: PMC4716018

Genes

PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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