Article
Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2014
Roulis Manolis, Nikolaou Christoforos, Kotsaki Elena, Kaffe Eleanna, Karagianni Niki, Koliaraki Vasiliki, Salpea Klelia, Ragoussis Jiannis, Aidinis Vassilis, Martini Eva, Becker Christoph, Herschman Harvey R, Vetrano Stefania, Danese Silvio, Kollias George
Abstract excerpt
Tumor progression locus-2 (Tpl2) kinase is a major inflammatory mediator in immune cell types recently found to be genetically associated with inflammatory bowel diseases (IBDs). Here we show that Tpl2 may exert a dominant homeostatic rather than inflammatory function in the intestine mediated specifically by subepithelial intestinal myofibroblasts (IMFs). Mice with complete or IMF-specific Tpl2 ablation are...
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