Article
Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.
Nature communications - 18 Nov 2021
Ryzhakov Grigory, Almuttaqi Hannah, Corbin Alastair L, Berthold Dorothée L, Khoyratty Tariq, Eames Hayley L, Bullers Samuel, Pearson Claire, Ai Zhichao, Zec Kristina, Bonham Sarah, Fischer Roman, Jostins-Dean Luke, Travis Simon P L, Kessler Benedikt M, Udalova Irina A
Abstract excerpt
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macrophages, here we identify protein-tyrosine kinase 2-beta (PTK2B/PYK2) as a putative IRF5 kinase. PYK2-deficient macrophages display impaired endogenous IRF5...
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