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Article

Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression.

ACS chemical biology - 20 Dec 2019

Reznik Nava, Kozer Noga, Eisenberg-Lerner Avital, Barr Haim, Merbl Yifat, London Nir

Abstract excerpt

FAT10 is a ubiquitin-like protein suggested to target proteins for proteasomal degradation. It is highly upregulated upon pro-inflammatory cytokines, namely, TNFα, IFNγ, and IL6, and was found to be highly expressed in various epithelial cancers. Evidence suggests that FAT10 is involved in cancer development and may have a pro-tumorigenic role. However, its biological role is still unclear, as well as its...

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PMID: 31794190
DOI: 10.1021/acschembio.9b00667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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