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Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responses

21 Feb 2025

Abstract excerpt

Tumor suppressor p53 is the most frequently mutated protein in cancer, possessing untapped immune-modulating capabilities in anticancer treatment. Here, we investigate the efficacy and underlying mechanisms of pharmacological reactivation of mutant p53 in treating spontaneous tumors in mice. In the p53 R279W (equivalent to the human hotspot R282W) mouse model developing spontaneous tumors, arsenic trioxide (ATO)...

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PMID: 39986271
DOI: 10.1016/j.xcrm.2025.101976

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