Article

Sense-and-respond payload delivery using a novel antigen-inducible promoter improves suboptimal CAR-T activation

2021-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor (CAR)-T cell therapies demonstrate the clinical potential of lymphocytes engineered with synthetic properties. However, CAR-T cells are ineffective in most solid tumors, partly due to inadequate activation of the infused lymphocytes at the site of malignancy. To selectively enhance anti-tumor efficacy without exacerbating off-target toxicities, CAR-T cells can be engine...

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Literature Corpus work: 4cfadd98-4526-530e-9aba-c38b5fc8b223
DOI: 10.1101/2021.04.02.438280

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