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Article

Modulating Mitochondrial DNA Heteroplasmy with Mitochondrially Targeted Endonucleases.

Annals of biomedical engineering - 1 Sept 2024

Mikhailov Nikita, Hämäläinen Riikka H

Abstract excerpt

Mitochondria, mainly known as energy factories of eukaryotic cells, also exert several additional signaling and metabolic functions and are today recognized as major cellular biosynthetic and signaling hubs. Mitochondria possess their own genome (mitochondrial DNA-mtDNA), that encodes proteins essential for oxidative phosphorylation, and mutations in it are an important contributor to human disease. The mtDNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36001180
DOI: 10.1007/s10439-022-03051-7
PMCID: PMC11329604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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