Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Manipulation of mitochondrial genes and mtDNA heteroplasmy.

Methods in cell biology - 1 Jan 2020

Bacman Sandra R, Gammage P A, Minczuk M, Moraes Carlos T

Abstract excerpt

Most patients with mitochondrial DNA (mtDNA) mutations have a mixture of mutant and wild-type mtDNA in their cells. This phenomenon, known as mtDNA heteroplasmy, provides an opportunity to develop therapies by selectively eliminating the mutant fraction. In the last decade, several enzyme-based gene editing platforms were developed to cleave specific DNA sequences. We have taken advantage of these enzymes to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to Chlorocebus aethiops
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Mitochondrial

Share to HeLa Cells

Share to Heteroplasmy

Share to Plasmids

Share to Transcription Activator-Like Effector Nucleases

Source

Identifiers

PMID: 32183972
DOI: 10.1016/bs.mcb.2019.12.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Manipulation of mitochondrial genes and mtDNA heteroplasmy.PMID 32183972Read ↗

Current strategies towards therapeutic manipulation of mtDNA heteroplasmy.Semantic proximity Read ↗

The use of mitochondria-targeted endonucleases to manipulate mtDNA.Semantic proximity Read ↗

Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective.Semantic proximity Read ↗

Development of mitochondrial gene-editing strategies and their potential applications in mitochondrial hereditary diseases: a review.Semantic proximity Read ↗

Tools for editing the mammalian mitochondrial genome.Semantic proximity Read ↗

Therapeutic potential of engineering the mitochondrial genome.Semantic proximity Read ↗

Modulating Mitochondrial DNA Heteroplasmy with Mitochondrially Targeted Endonucleases.Semantic proximity Read ↗

Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease.Semantic proximity Read ↗

Gene Therapy Tools for Diseases Caused by Mutations of the Mitochondrial Genome.Semantic proximity Read ↗

The potential of mitochondrial genome engineering.Semantic proximity Read ↗

Manipulation of Murine Mitochondrial DNA Heteroplasmy with mtZFNs.Semantic proximity Read ↗

Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.