Article

De novo design of RNA pseudoknots with deep learning

2026-05-22

Abstract excerpt

RNA design has been hindered by the limited accuracy of 3D structure prediction. Here, we show that intricate RNA structures can be generated with current deep learning tools through accurate de novo design of pseudoknot secondary structures. In an Eterna competition involving 57 pseudoknots, generative AI methods matched experienced human designers in solving most blind challenges, evaluated by single-nucleotide-...

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Literature Corpus work: 053b871a-3f61-558b-a0cf-441cc223528b
DOI: 10.64898/2026.05.21.726960

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