Article

Low protein expression of LZTR1 in hepatocellular carcinoma triggers tumorigenesis via activating the RAS/RAF/MEK/ERK signaling

2023-02-17

Abstract excerpt

<title>Abstract</title> <p>LZTR1 is a substrate specific adaptor for E3 ligase involved in ubiquitination and degradation of RAS GTPases, which inhibits the RAS/RAF/MEK/ERK signaling to suppress tumor progression. However, it’s still unknown whether LZTR1 destabilizes RAS GTPases to suppress HCC progression by inhibiting such signaling pathway. Lenvatinib is the first-line drug for the treatment of advanced HCC,...

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Literature Corpus work: 908ad6ab-eb65-5b2c-9e44-0be42c66f1bd
DOI: 10.21203/rs.3.rs-2587262/v1

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