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Article

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).

Molecular psychiatry - 1 Oct 2017

Clarke T-K, Adams M J, Davies G, Howard D M, Hall L S, Padmanabhan S, Murray A D, Smith B H, Campbell A, Hayward C, Porteous D J, Deary I J, McIntosh A M

Abstract excerpt

Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B, are strongly associated with alcohol consumption but have limited impact in European populations where they are found at low frequency. We performed a genome-wide association study (GWAS) of self-reported...

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Identifiers

PMID: 28937693
DOI: 10.1038/mp.2017.153
PMCID: PMC5622124

Genes

KLB
ADH5
ALDH2
CADM2
DRD2
GCKR

Provenance

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