Article
Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2011
Davidson Scott, Lear Marissa, Shanley Lynne, Hing Benjamin, Baizan-Edge Amanda, Herwig Annika, Quinn John P, Breen Gerome, McGuffin Peter, Starkey Andrew, Barrett Perry, MacKenzie Alasdair
Abstract excerpt
The expression of the galanin gene (GAL) in the paraventricular nucleus (PVN) and in the amygdala of higher vertebrates suggests the requirement for highly conserved, but unidentified, regulatory sequences that are critical to allow the galanin gene to control alcohol and fat intake and modulate mood. We used comparative genomics to identify a highly conserved sequence that lay 42 kb 5' of the human GAL...
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