Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.

Molecular psychiatry - 1 Jan 2018

Polimanti R, Kaufman J, Zhao H, Kranzler H R, Ursano R J, Kessler R C, Gelernter J, Stein M B

Abstract excerpt

Traumatic life experiences are associated with alcohol use problems, an association that is likely to be moderated by genetic predisposition. To understand these interactions, we conducted a gene-by-environment genome-wide interaction study (GEWIS) of alcohol use problems in two independent samples, the Army STARRS (STARRS, N=16 361) and the Yale-Penn (N=8084) cohorts. Because the two cohorts were assessed using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Gene-Environment Interaction

Share to Genome-Wide Association Study

Share to Life Change Events

Share to Risk Factors

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 28265120
DOI: 10.1038/mp.2017.24
PMCID: PMC5589475

Genes

PRKG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.PMID 28265120Read ↗

Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.Semantic proximity Read ↗

The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G × E effects.Semantic proximity Read ↗

Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations.Semantic proximity Read ↗

Genetic Advances in Post-traumatic Stress Disorder.Semantic proximity Read ↗

FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students.Semantic proximity Read ↗

Lifetime cannabis use and childhood trauma associated with CNR1 genetic variants increase the risk of psychosis: findings from the STREAM study.Semantic proximity Read ↗

Association of Stress-Related Genetic Polymorphisms and Stressful Life Events With Alcohol Use Disorder in a Brazilian Population.Semantic proximity Read ↗

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.Semantic proximity Read ↗

Genetic influences on the development of alcoholism.Semantic proximity Read ↗

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathwaysSemantic proximity Read ↗

A statistical genetic investigation of psychiatric resilience.Semantic proximity Read ↗

Psychiatric symptoms in adolescents: FKBP5 genotype--early life adversity interaction effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.