Article

Antibody Repertoires of Four- and Five-Feature Translocus Mice Carrying Human Immunoglobulin Heavy Chain and κ and λ Light Chain Yeast Artificial Chromosomes

1999-12-01

Abstract excerpt

Abstract We have produced mice that carry the human Ig heavy (IgH) and both κ and λ light chain transloci in a background in which the endogenous IgH and κ loci have been inactivated. The B lymphocyte population in these translocus mice is restored to about one-third of normal levels, with preferential (3:1) expression of human λ over human κ. Human IgM is found in the serum at levels between 50 and 400 μg/ml and...

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Literature Corpus work: 9351acd2-4bbd-5fb3-b7a4-f4a47d6c676f
DOI: 10.4049/jimmunol.163.12.6898

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