Article

4-Nitrobenzoate inhibits 4-hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

2025-06-10

Abstract excerpt

Ubiquinone (UQ) is a critical component of the electron transport chain in Plasmodium falciparum , the etiological agent of human malaria. The first step in UQ biosynthesis is the condensation of 4-hydroxybenzoate (4-HB) and an isoprenic chain by the enzyme 4-hydroxybenzoate polyprenyltransferase (4-HPT; COQ2 gene). Atovaquone (AV), an antimalarial drug, competes with ubiquinol (UQH 2 ) for binding to the mitoch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 932445d6-fc59-58f0-bd13-947142f1cdb9
DOI: 10.1101/2025.06.10.658244

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

4-Nitrobenzoate inhibits 4-hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacyDOI 10.1101/2025.06.10.658244Read

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc1 Catalytic Turnover and Protein ExpressionSemantic proximity Read

Structure-based therapeutic development against the Apicomplexan parasitesSemantic proximity Read

Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors.Semantic proximity Read

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.Semantic proximity Read

Molecular and biochemical pharmacology of mitochondrial enzymes in the malaria parasite Plasmodium falciparumSemantic proximity Read

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.Semantic proximity Read

Therapeutics development against the Apicomplexa parasites Plasmodium falciparum and Toxoplasma gondiiSemantic proximity Read

Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex.Semantic proximity Read

A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.Semantic proximity Read

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.Semantic proximity Read

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance.Semantic proximity Read

A Theileria annulata parasite with a single mutation, methionine 128 to isoleucine (M128I), in cytochrome B is resistant to buparvaquone.Semantic proximity Read