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Article

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

The Journal of biological chemistry - 10 Jun 2005

Baldwin Jeffrey, Michnoff Carolyn H, Malmquist Nicholas A, White John, Roth Michael G, Rathod Pradipsinh K, Phillips Margaret A

Abstract excerpt

Plasmodium falciparum is the causative agent of the most serious and fatal malarial infections, and it has developed resistance to commonly employed chemotherapeutics. The de novo pyrimidine biosynthesis enzymes offer potential as targets for drug design, because, unlike the host, the parasite does not have pyrimidine salvage pathways. Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial...

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Identifiers

PMID: 15795226
DOI: 10.1074/jbc.M501100200

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DHODH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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