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Article

Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex.

Parasitology international - 1 Jun 2015

Siregar Josephine E, Kurisu Genji, Kobayashi Tamaki, Matsuzaki Motomichi, Sakamoto Kimitoshi, Mi-ichi Fumika, Watanabe Yoh-ichi, Hirai Makoto, Matsuoka Hiroyuki, Syafruddin Din, Marzuki Sangkot, Kita Kiyoshi

Abstract excerpt

Atovaquone, a coenzyme Q analogue has been indicated to specifically target the cytochrome bc1 complex of the mitochondrial respiratory chain in the malarial parasite and other protozoan. Various mutations in the quinone binding site of the cytochrome b gene of Plasmodium spp. such as M133I, L144S, L271V, K272R, Y268C, Y268S, Y268N, and V284F are suggesting to associate with resistance to atovaquone. There is no...

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PMID: 25264100
DOI: 10.1016/j.parint.2014.09.011

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Related research

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Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex.PMID 25264100Read ↗

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