Article
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
PLoS pathogens - 1 Jul 2015
Khare Shilpi, Roach Steven L, Barnes S Whitney, Hoepfner Dominic, Walker John R, Chatterjee Arnab K, Neitz R Jeffrey, Arkin Michelle R, McNamara Case W, Ballard Jaime, Lai Yin, Fu Yue, Molteni Valentina, Yeh Vince, McKerrow James H, Glynne Richard J, Supek Frantisek
Abstract excerpt
Unbiased phenotypic screens enable identification of small molecules that inhibit pathogen growth by unanticipated mechanisms. These small molecules can be used as starting points for drug discovery programs that target such mechanisms. A major challenge of the approach is the identification of the cellular targets. Here we report GNF7686, a small molecule inhibitor of Trypanosoma cruzi, the causative agent of...
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