Article

A novel animal model for neuroinflammation and white matter degeneration

2017-08-01

Abstract excerpt

Small interference RNA has been widely used to suppress gene expression. Three different short-hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal Drd1 expression. Transduction of mouse striatum with all 3 scAAV8-D1shRNA virus, but not the control scAAV8 virus, causes extensive neuroinflammation, demy...

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Identifiers and source

Literature Corpus work: 9318289a-1c70-5638-8e5c-f4f45b3a2d43
DOI: 10.7287/peerj.preprints.3117v1

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