Article

Highly conserved interaction profiles between clinically relevant mutants of the cytomegalovirus CDK-like kinase pUL97 and human cyclins: functional significance of cyclin H

2022-06-03

Abstract excerpt

<title>Abstract</title> <p>The complex network of host interaction of the human cytomegalovirus (HCMV) involves the regulatory protein kinase pUL97, which represents a viral cyclin-dependent kinase (CDK) ortholog. pUL97 interacts with the three human cyclin types T1, H and B1, whereby the binding region of cyclin T1 and the pUL97 oligomerization region were both assigned to amino acids 231–280. We further address...

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Literature Corpus work: 9314c3b2-2b5d-5a5c-a196-326f51bdc8e2
DOI: 10.21203/rs.3.rs-1676959/v1

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