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Article

Functional and structural insights into HCMV terminase accessory proteins pUL77 and pUL93.

Journal of virology - 23 Oct 2025

Gourin C, Di Meo F, Delmon C, Alain S, Hantz S

Abstract excerpt

Human cytomegalovirus (HCMV) is a significant cause of morbidity and mortality in immunocompromised and congenitally infected patients. Current antiviral therapies, primarily targeting the viral DNA polymerase, are limited by toxicity and resistance, underscoring the need for novel therapeutic strategies. Letermovir (LTV), which targets the viral terminase complex (pUL56-pUL89-pUL51), has improved prophylaxis in...

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Identifiers

PMID: 40956108
DOI: 10.1128/jvi.01173-25
PMCID: PMC12548450

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Functional and structural insights into HCMV terminase accessory proteins pUL77 and pUL93.PMID 40956108Read ↗

Key domains involved in the interaction and assembly of the HCMV terminase complex.Semantic proximity Read ↗

Mutual Interplay between the Human Cytomegalovirus Terminase Subunits pUL51, pUL56, and pUL89 Promotes Terminase Complex FormationSemantic proximity Read ↗

The Human Cytomegalovirus UL51 Protein Is Essential for Viral Genome Cleavage-Packaging and Interacts with the Terminase Subunits pUL56 and pUL89Semantic proximity Read ↗

Interaction of human cytomegalovirus pUL52 with major components of the viral DNA encapsidation network underlines its essential role in genome cleavage-packagingSemantic proximity Read ↗

The C-terminal part of the human cytomegalovirus terminase subunit pUL51 is central for terminase complex assembly.Semantic proximity Read ↗

Identification of a short sequence in the HCMV terminase pUL56 essential for interaction with pUL89 subunitSemantic proximity Read ↗

Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53.Semantic proximity Read ↗

Conserved domains and structure prediction of human cytomegalovirus UL27 protein.Semantic proximity Read ↗

The human cytomegalovirus terminase complex as an antiviral target: a close-up viewSemantic proximity Read ↗

The Essential Human Cytomegalovirus Proteins pUL77 and pUL93 Are Structural Components Necessary for Viral Genome EncapsidationSemantic proximity Read ↗

Human Cytomegalovirus pUL79 Is an Elongation Factor of RNA Polymerase II for Viral Gene TranscriptionSemantic proximity Read ↗

Identification of a binding pocket of letermovir in the terminase subunit pUL56 of human cytomegalovirusSemantic proximity Read ↗

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