Article

Abemaciclib restricts HCMV replication by suppressing pUL97-mediated phosphorylation of SAMHD1

2023-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Human cytomegalovirus (HCMV) is a herpesvirus that causes life-threatening infections in newborns or immunosuppressed patients. For viral replication, HCMV establishes a network of cellular interactions, among others cyclin-dependent kinases (CDK). Furthermore, HCMV encodes pUL97, a viral kinase, which is a CDK-homologue. HCMV uses pUL97 in order to phosphorylate and thereby antagonize SAMHD1, a...

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Literature Corpus work: 4b5631e4-cc95-553c-9f9f-85adc1f4430c
DOI: 10.1101/2023.02.01.526617

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