Article

PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression

2024-12-20

Abstract excerpt

Regulatory T cells (T reg cells) play a critical role in suppressing anti-tumor immunity, often resulting in unfavorable clinical outcomes across numerous cancers. However, systemic T reg depletion, while augmenting anti-tumor responses, also triggers detrimental autoimmune disorders. Thus, dissecting the mechanisms by which T reg cells navigate and exert their functions within the tumor microenvironment (TME)...

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Literature Corpus work: 92fc9c19-2930-54f1-bbe4-5aee6c17a534
DOI: 10.1101/2024.12.16.628819

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