Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.

Nature - 28 Jun 2012

Cipolletta Daniela, Feuerer Markus, Li Amy, Kamei Nozomu, Lee Jongsoon, Shoelson Steven E, Benoist Christophe, Mathis Diane

Abstract excerpt

Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient excess promotes the accumulation and activation of leukocytes in visceral adipose tissue (VAT) and ultimately other tissues, leading to metabolic abnormalities such as insulin resistance, type-2 diabetes and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epididymis
Share to Hypoglycemic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Count

Share to Mice, Obese

Share to Pioglitazone

Share to PPAR gamma

Share to T-Lymphocytes, Regulatory

Share to Thiazolidinediones

Source

Open in PubMed Open full text

Identifiers

PMID: 22722857
DOI: 10.1038/nature11132
PMCID: PMC3387339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.PMID 22722857Read ↗

Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells.Semantic proximity Read ↗

Deciphering visceral adipose tissue regulatory T cells: Key contributors to metabolic healthSemantic proximity Read ↗

PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expressionSemantic proximity Read ↗

Functional Dichotomy of Developmental Foxp3 <sup>+</sup> Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese MiceSemantic proximity Read ↗

Rapid adipose tissue expansion triggers proliferation of memory adipose tissue T cells and accumulation of novel T helper 2 (Th2) regulatory cellsSemantic proximity Read ↗

A Unique Population: Adipose-Resident Regulatory T CellsSemantic proximity Read ↗

High-Fat Diet-Induced Dysregulation of Immune Cells Correlates with Macrophage Phenotypes and Chronic Inflammation in Adipose Tissue.Semantic proximity Read ↗

Visceral adipose tissue Tregs and the cells that nurture themSemantic proximity Read ↗

Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammationSemantic proximity Read ↗

PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.Semantic proximity Read ↗

A glimpse of the connection between PPARγ and macrophageSemantic proximity Read ↗

Mechanisms of Macrophage Polarization in Insulin Signaling and SensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.