Article

Obesity Potentiates T <sub>H</sub> 2 Immunopathology via Dysregulation of PPAR <i>γ</i>

2019-10-31

Abstract excerpt

How obesity affects immune function is not well understood. Clinically, obesity is strongly associated with severe T H 2 immunopathology 1-3 , though the physiological, cellular, and molecular underpinnings of this association remain obscure. Here, we demonstrate that obese mice are susceptible to severe atopic dermatitis (AD), a major manifestation of T H 2 immunopathology and disease burden in humans 4,5 . M...

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Literature Corpus work: f7c6196b-5f03-57b5-a6f4-4789e0810db6
DOI: 10.1101/825836

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