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Article

Independent variability of microtubule perturbations associated with dystrophinopathy

16 Sept 2016

Abstract excerpt

Absence of the protein dystrophin causes Duchenne muscular dystrophy. Dystrophin directly binds to microtubules in vitro, and its absence in vivo correlates with disorganization of the subsarcolemmal microtubule lattice, increased detyrosination of α-tubulin, and altered redox signaling. We previously demonstrated that the dystrophin homologue utrophin neither binds microtubules in vitro nor rescues microtubule...

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PMID: 28171583
DOI: 10.1093/hmg/ddw318

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