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Article

Microtubule binding distinguishes dystrophin from utrophin

31 Mar 2014

Abstract excerpt

Dystrophin and utrophin are highly similar proteins that both link cortical actin filaments with a complex of sarcolemmal glycoproteins, yet localize to different subcellular domains within normal muscle cells. In mdx mice and Duchenne muscular dystrophy patients, dystrophin is lacking and utrophin is consequently up-regulated and redistributed to locations normally occupied by dystrophin. Transgenic...

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PMID: 24706788
DOI: 10.1073/pnas.1323842111

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