Article
Dystrophic Dmdmdx rats show early neuronal changes (increased S100β and Tau5) at 8 months, supporting severe dystropathology in this rodent model of Duchenne muscular dystrophy.
Molecular and cellular neurosciences - 1 Oct 2020
Krishnan Vidya S, Thanigaiarasu Lakshana P, White Robert, Crew Rachael, Larcher Thibaut, Le Guiner Caroline, Grounds Miranda D
Abstract excerpt
The intrinsic necrosis of skeletal muscles in animal models of Duchenne muscular dystrophy (DMD) damages neuromuscular junctions (NMJs) with progressively altered NMJs associated with denervation and premature changes in dystrophic nerves. In the mdx mouse model of DMD, the proteins S100β and Tau5 are significantly increased in sciatic nerves by 13 months (M) of age, far earlier (by 9 M) than in normal wildtype...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.