Article

Disruption of folate metabolism causes poor alignment and spacing of mouse conceptuses for multiple generations

2021-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Abnormal uptake or metabolism of folate increases risk of human pregnancy complications, though the mechanism is unclear. Here, we explore how defective folate metabolism influences early development by analysing mice with an Mtrr gt hypomorphic mutation. MTRR is necessary for methyl group utilisation from the folate cycle, and the Mtrr gt allele disrupts this process. We show that the spectru...

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Literature Corpus work: 92f13524-a732-50ae-98a6-d7375357ec7a
DOI: 10.1101/2021.06.11.448112

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