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Article

Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice.

Molecular genetics and metabolism - 1 Jul 2008

Deng Liyuan, Elmore C Lee, Lawrance Andrea K, Matthews Rowena G, Rozen Rima

Abstract excerpt

Low dietary folate and polymorphisms in genes of folate metabolism can influence risk for pregnancy complications and birth defects. Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent enzyme. A polymorphism in MTRR (p.I22M), present in the homozygous state in 25% of many populations, may increase risk for neural tube defects. To examine...

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Source

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Identifiers

PMID: 18413293
DOI: 10.1016/j.ymgme.2008.03.004
PMCID: PMC3110750

Genes

MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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