Article

RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1α

2023-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Adipose thermogenesis involves specialized mitochondrial function that counteracts metabolic disease through dissipation of chemical energy as heat. However, inflammation present in obese adipose tissue can impair oxidative metabolism. Here, we show that PGC1α, a key governor of mitochondrial biogenesis and thermogenesis, is negatively regulated at the level of mRNA translation by the little-kno...

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Literature Corpus work: 92d989ea-f0d3-5c5c-ac65-37e5c5a96430
DOI: 10.1101/2023.01.06.522985

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