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Article

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

19 Apr 2023

Abstract excerpt

Obesity incidence is increasing worldwide with the urgent need to identify new therapeutics. Sex differences in immune cell activation drive obesity-mediated pathologies where males are more susceptible to obesity comorbidities and exacerbated inflammation. Here, we demonstrate that the macrophage-secreted protein RELMα critically protects females against high-fat diet (HFD)-induced obesity. Compared to male...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 37162190
DOI: 10.7554/elife.86001

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