Article

Inhibition of TFIIH translocase reveals a novel lncRNA regulatory network at the BRCA1 locus

2025-03-13

Abstract excerpt

<h4>Background</h4> Regulation of gene transcription is an essential early response to a broad variety of cellular stress. Paradoxically, pharmacological inhibition of an RNA polymerase II transcription initiation factor, XPB, induces a stress response that overactivates transcription of a subset of transcripts, including lncRNAs. However, the mechanisms enabling selective transcription under global initiation bl...

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Literature Corpus work: 92a98e28-8597-555f-97fe-76a2ab753295
DOI: 10.1101/2025.03.11.642677

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