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Article

Is TFIIH the new Achilles heel of cancer cells?

9 Aug 2017

Abstract excerpt

TFIIH is a 10-subunit complex involved in transcription and DNA repair. It contains several enzymatic activities including a ATP-dependent DNA translocase in XPB and a cyclin-dependent kinase in CDK7. Recently the discovery of several XPB and CDK7 inhibitors with specific impact on the transcriptional addiction of many tumors pinpointed these activities as potential target in cancer chemotherapy. Unexpectedly a...

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PMID: 28792271
DOI: 10.1080/21541264.2017.1331723

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