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Article

Shared polygenic susceptibility to treatment response in severe affective and psychotic disorders: Evidence from GWAS data sets.

Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2025

Facal Fernando, Costas Javier

Abstract excerpt

While schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) genetically correlate, the pleiotropy underlying response/resistance to drugs used in these disorders has not been investigated. The aim of this study is to analyze the genetic relationship between treatment-resistant schizophrenia (TRS), response to lithium in BD (respLi) and response to antidepressants in MDD (respAD) using the...

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Antidepressive Agents
Antipsychotic Agents
Bipolar Disorder
Major Depressive Disorder
Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psychotic Disorders

Treatment Outcome

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PMID: 39490915
DOI: 10.1016/j.pnpbp.2024.111183

Genes

MAP2K1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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