Article
Investigating the shared genetic architecture between schizophrenia and body mass index.
Molecular psychiatry - 1 Jun 2023
Yu Yuefeng, Fu Yanqi, Yu Yuetian, Tang Mengjun, Sun Ying, Wang Yuying, Zhang Kun, Li Huixia, Guo Hui, Wang Bin, Wang Ningjian, Lu Yingli
Abstract excerpt
Evidence for reciprocal comorbidity of schizophrenia (SCZ) and body mass index (BMI) has grown in recent years. However, little is known regarding the shared genetic architecture or causality underlying the phenotypic association between SCZ and BMI. Leveraging summary statistics from the hitherto largest genome-wide association study (GWAS) on each trait, we investigated the genetic overlap and causal...
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