Article

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

2023-07-07

Abstract excerpt

<h4>Summary</h4> Although the intestinal tract is a major site of reactive oxygen species (ROS) generation, the mechanisms by which antioxidant defense in gut T cells contribute to intestinal homeostasis are currently unknown. Here we show, using T cell-specific ablation of the catalytic subunit of glutamate cysteine ligase ( Gclc ), that the ensuing loss of glutathione (GSH) impairs the production of gut-protec...

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Literature Corpus work: 927764ce-636f-5b97-943f-fa9620589878
DOI: 10.1101/2023.07.06.547932

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