Article

Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease

2025-02-11

Abstract excerpt

<h4>Summary</h4> Enterocolitis is a common and potentially deadly manifestation of Hirschsprung disease (HSCR) but disease mechanisms remain poorly defined. Unexpectedly, we discovered that diet can dramatically affect the lifespan of a HSCR mouse model ( Piebald lethal , sl/sl ) where affected animals die from HAEC complications. In the sl/sl model, diet alters gut microbes and metabolites, leading to changes...

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Literature Corpus work: 12d5e378-198a-5307-8ec0-1934c0473cee
DOI: 10.1101/2025.02.10.637436

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