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Article

Trade-Offs Between Hepatic Host Defense and Metabolic Programs Underlie Sex-Biased Diseases

2022-01-10

Abstract excerpt

<h4>ABSTRACT</h4> Current concepts in evolutionary medicine propose that trade-offs and mismatches with a shifting environment increase disease risk. While biological sex also impacts disease prevalence, contributions of environmental pressures to sex-biased diseases remain unexplored. Here, we show that sex-dependent hepatic programs confer a robust (~300%) survival advantage for male mice during lethal bacteria...

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Literature Corpus work
926e9fe8-c5f4-57ca-9208-1f90e3141859
DOI
10.1101/2022.01.07.475423
Open publication

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Trade-Offs Between Hepatic Host Defense and Metabolic Programs Underlie Sex-Biased DiseasesDOI 10.1101/2022.01.07.475423
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