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Hepatic immune environment differences among common mouse strains in models of MASH and liver cancer

1 Mar 2025

Abstract excerpt

Background & Aims Inbred mouse strains are critical tools for studying immune regulation of metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinoma (HCC). Here, we profiled mouse strain-associated hepatic immune differences, and performed mice–human cross-species immune comparisons. Methods Immune landscapes of C57BL/6, BALB/c, and FVB/N mice were compared under healthy, MASH, or HCC...

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PMID: 40342632
DOI: 10.1016/j.jhepr.2025.101380

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