Article

MicroSEC: Sequence error filtering pipeline for formalin-fixed and paraffin-embedded samples

2021-01-28

Abstract excerpt

<title>Abstract</title> <p>The clinical sequencing of tumors is usually performed on formalin-fixed, paraffin-embedded (FFPE) samples and results in many sequencing errors. Most of these errors are detected in chimeric reads caused by single-strand DNA molecules with microhomology. Our filtering pipeline, MicroSEC, focuses on the uneven distribution of mutations in each read and removes the sequencing errors in F...

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Literature Corpus work: 923aa9a7-aaef-5452-9050-7651b7b93aa4
DOI: 10.21203/rs.3.rs-153650/v1

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