Article

Genomic Signatures of Pre-Resistance in Mycobacterium tuberculosis

2021-05-25

Abstract excerpt

<title>Abstract</title> <p>Recent advances in bacterial whole-genome sequencing have resulted in the identification of a comprehensive catalogue of genomic signatures of antibiotic resistance in Mycobacterium tuberculosis. With a view to pre-empting the emergence of drug-resistance, we hypothesized that pre-existing balanced polymorphisms in drug susceptible genotypes (“pre-resistance mutations”) could increase t...

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Literature Corpus work: 92318bf2-e9c6-5140-834f-a29024f52dc7
DOI: 10.21203/rs.3.rs-364747/v1

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