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Article

Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru.

PloS one - 1 Jan 2017

Grandjean Louis, Gilman Robert H, Iwamoto Tomatada, Köser Claudio U, Coronel Jorge, Zimic Mirko, Török M Estee, Ayabina Diepreye, Kendall Michelle, Fraser Christophe, Harris Simon, Parkhill Julian, Peacock Sharon J, Moore David A J, Colijn Caroline

Abstract excerpt

BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and preventive strategies. METHODS: Here, we use novel genome-wide analysis techniques to identify polymorphisms that are associated with drug resistance, adaptive evolution and the structure...

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Share to Drug Resistance, Multiple, Bacterial
Share to Genes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium tuberculosis

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Share to Polymorphism, Single Nucleotide

Share to Tuberculosis, Multidrug-Resistant

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Identifiers

PMID: 29281674
DOI: 10.1371/journal.pone.0189838
PMCID: PMC5744980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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