Back to search

Article

Genome wide association with quantitative resistance phenotypes in <i>Mycobacterium tuberculosis</i> reveals novel resistance genes and regulatory regions

2018-09-27

Abstract excerpt

Drug resistance is threatening attempts at tuberculosis epidemic control. Molecular diagnostics for drug resistance that rely on the detection of resistance-related mutations could expedite patient care and accelerate progress in TB eradication. We performed minimum inhibitory concentration testing for 12 anti-TB drugs together with Illumina whole genome sequencing on 1452 clinical Mycobacterium tuberculosis (MTB...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ac260eab-e9bc-5e08-97d7-dd9b35d37c56
DOI
10.1101/429159
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genome wide association with quantitative resistance phenotypes in <i>Mycobacterium tuberculosis</i> reveals novel resistance genes and regulatory regionsDOI 10.1101/429159
GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions.Semantic proximity
Genome-wide association studies of global <i>Mycobacterium tuberculosis</i> resistance to thirteen antimicrobials in 10,228 genomesSemantic proximity
Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms.Semantic proximity
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approachSemantic proximity
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.Semantic proximity
Quantitative measurement of antibiotic resistance in <i>Mycobacterium tuberculosis</i> reveals genetic determinants of resistance and susceptibility in a target gene approachSemantic proximity
Regression for accurate and sensitive grading of mutations diagnostic of antibiotic resistance in<i>Mycobacterium tuberculosis</i>Semantic proximity
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.Semantic proximity
Whole genome sequencing for drug resistance profile prediction in <i>Mycobacterium tuberculosis</i>Semantic proximity
The mutational signatures of poor treatment outcomes on the drug-susceptible <i>Mycobacterium tuberculosis</i> genomeSemantic proximity
Leveraging large-scale Mycobacterium tuberculosis whole genome sequence data to characterise drug-resistant mutations using machine learning and statistical approaches.Semantic proximity
Signatures of selection at drug resistance loci in <i>Mycobacterium tuberculosis</i>Semantic proximity
Select a neighboring publication to make it the new centre.