Article

Balance between protective and pathogenic immune responses to pneumonia in the neonatal lung enforced by gut microbiota

2021-09-27

Abstract excerpt

While modern clinical practices like cesarean sections and perinatal antibiotics have improved infant survival, treatment with broad-spectrum antibiotics alters intestinal microbiota and causes dysbiosis. Infants exposed to perinatal antibiotics have an increased likelihood of life-threatening infections, including pneumonia. Here, we investigated how gut microbiota sculpt pulmonary immune responses, promoting rec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30ca24ad-95d3-5daa-af91-8f7a679a6d57
DOI: 10.1101/2021.09.27.461705

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Balance between protective and pathogenic immune responses to pneumonia in the neonatal lung enforced by gut microbiotaDOI 10.1101/2021.09.27.461705Read

Understanding respiratory microbiome–immune system interactions in health and diseaseSemantic proximity Read

Inflammation as a Modulator of Host Susceptibility to Pulmonary Influenza, Pneumococcal, and Co-InfectionsSemantic proximity Read

Perinatal maternal antibiotic exposure augments lung injury in offspring in experimental bronchopulmonary dysplasia.Semantic proximity Read

Placental and fetal microbiota in rhesus macaque: a case study using metagenomic sequencingSemantic proximity Read

Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a humanized mouse modelSemantic proximity Read

Paired Airway and Blood Multiomics Defines Coordinated Immune Adaptation Across the Airway–Blood Axis in Preterm InfantsSemantic proximity Read

Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primatesSemantic proximity Read

The landscape of antibiotic resistance genes in the nasopharynx of preterm infants: Prolonged signature of hospitalization and effects by antibioticsSemantic proximity Read

Early life inter-kingdom interactions shape the immunological environment of the airwaysSemantic proximity Read

Prenatal Exposure to Bacterial Extracellular Vesicles Influences Fetal Gut Immunity and Immune ProgrammingSemantic proximity Read

Respiratory microbiome and epithelial interactions shape immunity in the lungsSemantic proximity Read

Unravel the landscape of antibiotic resistance determinants in the nasopharynx and the impact of antibiotics: a longitudinal study of preterm infantsSemantic proximity Read