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Article

DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice

4 Jun 2018

Abstract excerpt

Pediatric acute lung injury, usually because of pneumonia, has a mortality rate of more than 20% and an incidence that rivals that of all childhood cancers combined. CD4 + T-cells coordinate the immune response to pneumonia but fail to function robustly among the very young, who have poor outcomes from lung infection. We hypothesized that DNA methylation represses a mature CD4 + T-cell transcriptional program in...

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PMID: 29866884
DOI: 10.1074/jbc.ra118.003589

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