Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes.

doi:10.1038/s41467-026-73222-w

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Article

Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes.

Nature communications - 3 Jun 2026

Maurin Lucas, Marselli Lorella, Boissel Mathilde, Pascat Vincent, Suleiman Mara, Henriques Emma, De Luca Carmela, Ning Lijiao, Fourcot Marie, Tesi Marta, Toussaint Bénédicte, Amanzougarene Souhila, Derhourhi Mehdi, Oger Frédérik, Burdet Frederic, Canouil Mickael, Cnop Miriam, Ibberson Mark, Bonnefond Amélie, Marchetti Piero, Froguel Philippe, Khamis Amna

Abstract excerpt

Age is the strongest risk factor for type 2 diabetes, yet their independent contribution to pancreatic islet dysfunction remains unclear. We integrate DNA methylation, transcriptomic, and genotyping data from 144 islet donors. We identify 996 age- and 902 T2D-associated CpGs with minimal overlap, and 251 age- and 310 diabetes CpG target genes, usually distant from the CpG. Age-linked CpGs are enriched in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42236498
DOI: 10.1038/s41467-026-73222-w
PMCID: PMC13233915

Genes

KLHL42

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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