Article
BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features.
Annals of hematology - 1 Aug 2016
Neuendorff Nina Rosa, Burmeister Thomas, Dörken Bernd, Westermann Jörg
Abstract excerpt
BCR-ABL-positive acute myeloid leukemia (AML) is a rare subtype of AML that is now included as a provisional entity in the 2016 revised WHO classification of myeloid malignancies. Since a clear distinction between de novo BCR-ABL+ AML and chronic myeloid leukemia (CML) blast crisis is challenging in many cases, the existence of de novo BCR-ABL+ AML has been a matter of debate for a long time. However, there is...
Topics
- Acute Disease
- Algorithms
- Diagnosis, Differential
- Fusion Proteins, bcr-abl
- Gene Expression Regulation, Leukemic
- Humans
- Leukemia, Myeloid
- Mutation
- Nuclear Proteins
- Nucleophosmin
- Prognosis