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BCR/ABL1-Like Acute Lymphoblastic Leukemia: From Diagnostic Approaches to Molecularly Targeted Therapy.

Acta haematologica - 1 Jan 2022

Płotka Anna, Lewandowski Krzysztof

Abstract excerpt

BACKGROUND: BCR/ABL1-like acute lymphoblastic leukemia is a newly recognized high-risk subtype of ALL, characterized by the presence of genetic alterations activating kinase and cytokine receptor signaling. This subtype is associated with inferior outcomes, compared to other B-cell precursor ALL. SUMMARY: The recognition of BCR/ABL1-like ALL is challenging due to the complexity of underlying genetic alterations....

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Fusion Proteins, bcr-abl
Gene Rearrangement
Molecular Targeted Therapy
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34818644
DOI: 10.1159/000519782

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