Article

Detection of an Activating Mutation of the Thyrotropin Receptor in a Case of an Autonomously Hyperfunctioning Thyroid Insular Carcinoma

1997-03-01

Abstract excerpt

Thyroid carcinomas, even when well differentiated, usually appear as hypofunctioning at scintigraphy. We report a case of an aggressive insular thyroid carcinoma presenting as an autonomously functioning thyroid nodule and causing severe thyrotoxicosis. The tumor was metastatic to a cervical lymph node and both lungs. An activating mutation of the TSH receptor gene in both the primary tumor and the lymph node meta...

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Identifiers and source

Literature Corpus work: 91f27254-3c48-5d8a-b78c-425f25ff36e6
DOI: 10.1210/jc.82.3.735

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